Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease associated with articular, extra-articular, and systemic effects.1

Approximately 1.5 million people in the US are affected by RA, and about 41 per 100,000 adults are diagnosed each year. The incidence of RA rises with age and peaks between ages 65 and 74 years.2

RA accounts for around 4.8 million disability-adjusted life years, a measure that represents the loss of “healthy” life caused by disease.3

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The cause and onset triggers of RA are unknown but involve a complex interplay of factors, including genotype, chance, and environmental triggers of immune system activation, such as infectious agents (ie, viruses, bacteria, and fungi), smoking, periodontitis, and gut microbiome.4

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Inflammation pathways in RA5

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Inflammation Pathways in Rheumatoid Arthritis (RA)1-10

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