Psoriatic Arthritis

Psoriatic arthritis (PsA) is an inflammatory arthritis that is associated with the presence of psoriasis but is usually seronegative for rheumatoid factor.1

PsA may occur in 0.1%−0.25% of the general population in the US and typically appears in patients 30−50 years old but may occur at anytime, including childhood.2

Up to 42% of patients with psoriasis will develop PsA,3 with psoriatic skin symptoms preceding the arthritic symptoms in the majority of patients.3,4

Patients with both psoriasis and PsA usually are affected by plaque psoriasis but may present with other types (eg, pustular, guttate).3,5

border-line

Symptoms of PsA may range from mild to very severe and may include frequent morning stiffness with or without immobility.2 Erosive and deforming arthritis occurs in 40%−60% of patients,2 with erosive changes seen despite treatment and clinical improvement.5

border-line

Inflammation pathways in PsA6-8

PsA is a chronic heterogeneous disease whose pathogenesis is unknown; however, genetic, environmental, and immunologic factors play major roles.3

pathways-img

Inflammation Pathways in Psoriatic Arthritis (PsA)1-9

This image is interactable. Click on the numbers and cell images for additional information.